<p>[Problem] The purpose of the present invention is to provide a preparation which has an effect of further promoting cellular immunity when used in an adjuvant or in a method for removing an immunosuppression mechanism. [Solution] Provided is a sugar-coated liposome (particularly a mannose-coated liposome) which can activate a CTL in an MHC-class II antigen-independent (CD4+T cell-independent) manner when administered together with an MHC class I antigen. Particularly provided is a sugar-coated liposome which has a particle diameter of 100-1100 nm and/or in which the molar ratio of a sugar-modified lipid to a lipid is 0.00075-0.075.</p>
申请公布号
EP2735314(A1)
申请公布日期
2014.05.28
申请号
EP20120779704
申请日期
2012.05.01
申请人
BIOMEDCORE INC.;SAPPORO MEDICAL UNIVERSITY;TOKAI UNIVERSITY EDUCATIONAL SYSTEM;TORIGOE, TOSHIHIKO;SATO, NORIYUKI