发明名称 |
2',3'-DIDEOXY-2'-alpha-FLUORO-2'-beta-C-METHYLNUCLEOSIDES AND PRODRUGS THEREOF |
摘要 |
<p>The present invention is made to fulfill the foregoing need. Since most of antiHN nucleosides are 2′,3′-dideoxynucleosides that have been proved to be excellent substrates of kinases for the phosphorylations. 2′,3′-Dideoxy-2,-a-fluoro-2′-{3-C-methyl-nucleosides can be considered as one unique class of 2′,3′-dideoxynucleosides to be good substrate of kinases because fluorine mimics hydrogen. It also can be considered as ribo-nucleosides to incorporate into RNA of HCV because 2′-fluorine-a mimics 2′-a-OH group.</p> |
申请公布号 |
EP2734535(A2) |
申请公布日期 |
2014.05.28 |
申请号 |
EP20120814614 |
申请日期 |
2012.07.19 |
申请人 |
NANJING MOLECULAR RESEARCH, INC. |
发明人 |
CHANG, JUNBIAO;HUANG, QIANG;ZHOU, SUPING |
分类号 |
C07H19/16;A61K31/7076;A61P31/14;C07D307/33;C07H15/18;C07H19/207 |
主分类号 |
C07H19/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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