TNF-ALPHA-ANTIGEN-BINDING PROTEINS AGAINST WITH INCREASED FCRN BINDING FOR USE IN THERAPY

摘要

The present invention provides antigen binding proteins which bind specifically to TNF-alpha. For example novel variants of anti-TNF antibodies such as adalimumab which show increased binding to the FcRn receptor or increased half life compared to adalimumab. Also provided are compositions comprising the antigen binding proteins and uses of such compositions in treatment of disorders and disease.