摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: claimed invention relates to novel indole and benzomorpholine derivatives of a formula (I)or its pharmaceutically acceptable salt, where Rrepresents C-alkyl or Calkyl, substituted with C-cycloalkyl; Rrepresents halogeno; Rrepresents hydrogen; n equals 2, X represents -CHCH-O or -CH=CH-; Y represents -O- or -CR(OH)-; Rrepresents hydrogen or Calkyl. Invention also relates to a pharmaceutical composition based on formula (I) compound and a method of treatment or prevention of the said pathological states.EFFECT: obtained are novel compounds, which are positive allosteric modulators of matabotropic subtype 2 receptors (mGluR2), which are useful for treatment or prevention of neurological and psychiatric disorders, associated with glutamate dysfunction, and diseases, involving metabotropic subtype 2 receptors GluR2.22 cl, 2 tbl, 8 ex |