| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to novel compounds of formula(I) and pharmaceutically acceptable salts thereof, having the capacity to bind amyloid peptides and/or amyloids. In formula (I), EDG is an electron donor group, ?CE is a pi-coupling element and WSG is a water-soluble group. EDG is -NRR, where Rand Rindependently denote hydrogen, R-substituted or unsubstituted C-Calkyl, where Rand Rare optionally linked to form a R-substituted or unsubstituted 6-member heterocycloalkyl, where said 6-member heterocycloalkyl optionally contains a heteroatom selected from O or N, Ris an unsubstituted C-Calkyl or unsubstituted 6-member heterocycloalkyl, where said 6-member heterocycloalkyl contains a heteroatom selected from O or N. The pi-coupling element has the formula -L-(A)-L-(A)-L-, in which q and r are independently equal to 0 or 1 and at least one of q and r is equal to 1, Aand Adenote an unsubstituted group, L, Land Lindependently denote a bond or a binding group of formula, where x is an integer from 1 to 50. The water-soluble group is a R-substituted C-Calkyl orgroup, where Ris -ORor a R-substituted 5-member heterocycloalkyl containing two O atoms, Ris hydrogen, Ris an unsubstituted C-Calkyl and y is an integer from 1 to 50.EFFECT: invention relates to specific compounds of formula (I), pharmaceutical compositions and a method of detecting an amyloid peptide.14 cl, 11 dwg, 5 tbl, 11 ex |
