| 摘要 |
FIELD: chemistry.SUBSTANCE: group of inventions relates to adhesive hydrogel compositions intended for oral application. The hydrophilic pressure-sensitive bioadhesive is a non-covalent complex of a film-forming polymer with at least one of the following complementary components: cross-linking polymer agent, cross-linking oligomer agent, low-molecular weight substance, or with a mixture of at least two of said components, where the film-forming polymer and the cross-linking polymer agent are selected from a class of hydrophilic polymers. Components of the bioadhesive are taken in an amount which enables to obtain a complex which is characterised by adhesion to the surface of teeth and the lack of adhesion towards other tissues in the oral cavity with particular values glass transition temperature, modulus of elasticity G?, loss tangent, swelling degree in aqueous medium and swell ratio. The film-forming hydrophilic polymer is preferably contained in a higher concentration than other components of the adhesive, wherein the latter have complementary reactive functional groups which are capable of forming non-covalent hydrogen, electrostatic or ionic bonds with functional groups of the hydrophilic film-forming polymer. In a swollen state, the "smart" hydrophilic pressure-sensitive adhesive is softer than the dental substrate but harder than the mucosal tissues in the oral cavity. Also disclosed is a dental care composition which contains the pressure-sensitive bioadhesive and one or more active agents, such as teeth whitening agents, fluoride sources, antibacterial agents etc. The preferred teeth whitening agent is a peroxide.EFFECT: composition can be used as teeth whitening film-strips or gels.56 cl, 3 tbl, 27 ex |
