METHOD OF PRODUCING 2-OXO-2H-CYCLOHEPTA[B]FURAN ANALOGUE

摘要

This method of cheaply and easily producing a 2-oxo-2H-cyclohepta[b]furan analogue useful as a pharmaceutical intermediate with high purity and high yields. In this method, a 2-oxo-2H-cyclohepta[b]furan analogue represented by general formula (II) (R being a hydrogen atom or an optionally branched lower alkyl group (carbon number 1-5)) is produced by reacting, in an alcohol medium in the presence of an alkali metal hydroxide, malonic acid dimethyl esters with a 2-chlorotropone analogue represented by general formula (1) (R as above).