发明名称 PHOSPHOLIPIDE FLUORESCENT PROBE AND TEST-SYSTEM FOR DETERMINATION OF ACTIVITY OF A2 PHOSPHOLIPASE IN BLOOD SERUM
摘要 FIELD: biotechnologies.SUBSTANCE: phospholipide fluorescent probe characterised by the following name 1-[13-(4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacen-8-yl)tridecanoyl]-2-(10-{[(2-hydroxynaphthyl-1)azophenyl-4]azophenyl-4}decanoyl)-sn-glycero-3-phosphocholine, is used in the test system to determine activity of A2 phospholipase, group IIA (secFLA2(IIA)) in blood serum, which also contains vesicular and phospholipide matrix for inclusion of a probe, containing phosphatidyl choline, lisophosphatidyl choline and phosphatidyl glycerine, a buffer solution and A2 phospholipase of apitoxin as standard.EFFECT: invention makes it possible to reliably detect activity of secFLA2 in human blood serum in clinical conditions.2 cl, 5 dwg, 5 ex
申请公布号 RU2517538(C1) 申请公布日期 2014.05.27
申请号 RU20120149603 申请日期 2012.11.22
申请人 FEDERAL'NOE GOSUDARSTVENNOE BJUDZHETNOE UCHREZHDENIE NAUKI INSTITUT BIOORGANICHESKOJ KHIMII IM. AKADEMIKOV M.M. SHEMJAKINA I JU.A. OVCHINNIKOVA ROSSIJSKOJ AKADEMII NAUK (IBKH RAN);FEDERAL'NOE GOSUDARSTVENNOE BJUDZHETNOE UCHREZHDENIE "ROSSIJSKIJ KARDIOLOGICHESKIJ NAUCHNO-PROIZVODSTVENNYJ KOMPLEKS" MINISTERSTVA ZDRAVOOKHRANENIJA I SOTSIAL'NOGO RAZVITIJA ROSSIJSKOJ FEDERATSII (FGBU "RKNPK" MINZDRAVSOTSRAZVITIJA ROSSII);FEDERAL'NOE GOSUDARSTVENNOE UNITARNOE PREDPRIJATIE "GOSUDARSTVENNYJ NAUCHNYJ TSENTR "NAUCHNO-ISSLEDOVATEL'SKIJ INSTITUT ORGANICHESKIKH POLUPRODUKTOV I KRASITELEJ" (FGUP "GNTS "NIOPIK") 发明人 BOLDYREV IVAN ALEKSANDROVICH;ALEKSEEVA ANNA SERGEEVNA;MOLOTKOVSKIJ JULIAN GEORGIEVICH;VODOVOZOVA ELENA L'VOVNA;SAMOJLOVA ELENA VILENOVNA;KOROTAEVA ALEKSANDRA ALEKSEEVNA;POZDEEVA TAT'JANA ALEKSEEVNA
分类号 C12Q1/00;C07F5/05;G01N33/00 主分类号 C12Q1/00
代理机构 代理人
主权项
地址