发明名称 |
MICROBUBBLE COMPLEXES AND METHODS OF USE |
摘要 |
The present invention relates to a microbubble complex comprising a microbubble having an outer shell comprising a mixture of native and denatured albumin encapsulating a perfluorocarbon gas, a therapeutic agent, a bifunctional linker having one end attached to the therapeutic agent and the other attached to a ligand and wherein the ligand is bound to the other shell of the microbubble through hydrophobic interactions. Also included are methods for delivering the aforementioned microbubble complex to a tissue target. |
申请公布号 |
KR20140063697(A) |
申请公布日期 |
2014.05.27 |
申请号 |
KR20147006830 |
申请日期 |
2012.09.18 |
申请人 |
GENERAL ELECTRIC COMPANY |
发明人 |
SOOD ANUP;ROTHMAN JAMES E.;LOWERY LISA;BURCZAK JOHN;LIM HAE WON;MOHAN PRAVEENA |
分类号 |
A61K47/48;A61K48/00;C12N15/87 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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