Provided are recombinant mycobacteria having a mutation in annlaA gene or in a nuoG gene. Also provided are isolated and purified nlaA proteins and nuoG proteins from a mycobacterium. Additionally provided are isolated and purified nucleic acids comprising a recombinant nlaA gene or a recombinant nuoG gene. Further provided are methods of inducing an immune response in a mammal and methods of making a recombinant mycobacterium using the nlaA gene or the nuoG gene.
申请公布号
CA2597698(C)
申请公布日期
2014.05.27
申请号
CA20062597698
申请日期
2006.01.12
申请人
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
发明人
JACOBS, WILLIAM R., JR.;PORCELLI, STEVEN A.;BRIKEN, VOLKER;BRAUNSTEIN, MIRIAM