发明名称 |
Motor neurons developed from stem cells |
摘要 |
Provided is a method for directing differentiation of neural progenitors with a caudal and ventral specification into motor neurons including culturing neural progenitors in a culturing medium including a basic medium supplemented by at least one inhibitor of the Notch signaling pathway whereby the neural progenitors differentiate into postmitotic motor neurons. The resulting motor neurons may be used for drug development, as carriers, e.g. for gene therapy of protein delivery as well as for transplantation for the purpose of treating a motor neuron disease. |
申请公布号 |
US8735149(B2) |
申请公布日期 |
2014.05.27 |
申请号 |
US20090935427 |
申请日期 |
2009.04.05 |
申请人 |
REUBINOFF BENJAMIN;BEN SHUSHAN ETTI;AHARONOWIZ MICHAL;HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED |
发明人 |
REUBINOFF BENJAMIN;BEN SHUSHAN ETTI;AHARONOWIZ MICHAL |
分类号 |
C12N5/00;C12N5/02;C12N5/071;C12N5/0793;C12N5/0797 |
主分类号 |
C12N5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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