发明名称 |
Solid phase gold nanoparticle synthesis |
摘要 |
A method of synthesizing ligand-conjugated gold nanoparticles (AuNPs) is disclosed. The method comprises: a) providing an amine-modified silica particle; b) providing a solution comprising Au+3 ions; c) suspending the amine-modified silica particle in the solution comprising Au+3 ions; d) allowing the Au3+ ions to be adsorbed and/or immobilized onto the surface of the amine-modified silica particle; e) exposing the Au3+ ions immobilized onto the surface of the amine-modified silica particle to radiation to obtain bare gold nanoparticles (AuNPs) adsorbed and/or immobilized onto the surface of the amine-modified silica particle, wherein the bare AuNPs are without organic surface modifications; and f) reacting a ligand with the bare AuNPs adsorbed and/or immobilized onto the surface of the amine-modified SiNP and thereby obtain ligand-conjugated gold nanoparticles (AuNPs). |
申请公布号 |
US8734844(B2) |
申请公布日期 |
2014.05.27 |
申请号 |
US201113109438 |
申请日期 |
2011.05.17 |
申请人 |
LEE CHIA-HUNG;LIAO WEI-NENG;CHENG SHIH-HSUN;CHEN JEN-KUN;YANG CHUNG-SHI;LO LEU-WEI;HWU YEU-KUANG;LIN FONG-SIAN;NATIONAL HEALTH RESEARCH INSTITUTES |
发明人 |
LEE CHIA-HUNG;LIAO WEI-NENG;CHENG SHIH-HSUN;CHEN JEN-KUN;YANG CHUNG-SHI;LO LEU-WEI;HWU YEU-KUANG;LIN FONG-SIAN |
分类号 |
A61K9/14 |
主分类号 |
A61K9/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|