发明名称 |
Relaxin polypeptides comprising non-naturally encoded amino acids |
摘要 |
Modified relaxin polypeptides and their uses are provided. In one aspect, the disclosure provides a relaxin polypeptide comprising one or more non-naturally encoded amino acids. The polypeptide may be linked to a linker, polymer, or biologically active molecule. The serum half-life of the relaxin polypeptide may be enhanced relative to the unconjugated form. In another aspect, the disclosure provides methods of treating a patient having a disorder modulated by relaxin. |
申请公布号 |
US8735539(B2) |
申请公布日期 |
2014.05.27 |
申请号 |
US201113212101 |
申请日期 |
2011.08.17 |
申请人 |
KRAYNOV VADIM;KNUDSEN NICK;HEWET AHMA;DE DIOS KRISTINE;PINKSTAFF JASON;SULLIVAN LORRAINE;AMBRX, INC. |
发明人 |
KRAYNOV VADIM;KNUDSEN NICK;HEWET AHMA;DE DIOS KRISTINE;PINKSTAFF JASON;SULLIVAN LORRAINE |
分类号 |
C07K14/64;A61K38/17 |
主分类号 |
C07K14/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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