发明名称 |
BI- AND MONOSPECIFIC, ASYMMETRIC ANTIBODIES AND METHODS OF GENERATING THE SAME. |
摘要 |
An antibody is provided. The antibody comprises an Fc region and a Fab region, wherein: (i) the Fc region comprises two non-identical heavy chains, wherein at least one of the two non-identical heavy chains comprises an amino acid modification so as to form complementation between the two non-identical heavy chains thereby increasing the probability of forming heterodimers of the non-identical heavy chains and decreasing the probability of forming homodimers of identical heavy chains; and (ii) the Fab region comprises a first covalent link between a first heavy chain and a first light chain of the Fab region and a second covalent link between a second heavy chain and a second light chain of said Fab region, wherein a position of the first covalent link relative to the first heavy chain is different to a position of the second covalent link relative to the second heavy chain. Methods of generating same and uses thereof are also provided. |
申请公布号 |
MX2013010590(A) |
申请公布日期 |
2014.05.27 |
申请号 |
MX20130010590 |
申请日期 |
2012.03.15 |
申请人 |
RAMOT AT TEL-AVIV UNIVERSITY LTD. |
发明人 |
ITAI BENHAR;LILAACH VAKS |
分类号 |
C07K16/28;C07K16/00;C07K16/32 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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