| 摘要 |
Novel flavonoid compounds having anti-oxidant activity are described. The compounds and compositions have been shown to exhibit anti-oxidant properties and are particularly useful in the treatment of ischemia and reperfusion injuries. A method to chemically synthesize such flavonoid compounds and test their efficacy is also described. Such compounds and corresponding pharmaceutically acceptable derivatives and/or salts have uses in the areas of pharmaceuticals, nutraceutical, and veterinary applications. In particular, compounds of the general formula I are described: (see formula I) wherein: = denotes a single or double bond; and R1, R2, R3, R4, R5 are independently selected from H, OH or a group according to formula (Ia): -O-L-D-E (Ia) wherein: O is oxygen; i) L is a C=O group, D is an alkylene group with a chain length equivalent to 1 to 20 carbon atoms, and E is a substituted or unsubstituted carboxylic acid group, or ii) L and D are absent and E is an ester group according to formula (Ic): (see formula Ic) wherein: Q is a substituted or unsubstituted alkylene; W is O; and X is H, a substituted or unsubstituted alkyl, benzyl, or a mono-or divalent cationic salt, or an ammonium cationic salt; or its pharmaceutically acceptable salts; and provided that at least one of R1,R2, R3, R4, R5 other than H or OH. |
