| 摘要 |
A method for the genetic diagnostics of the sensorineural deafness in the children provides for ENT examination, audiometry, impedansometry, otoacoustic emission, tympanometry, and the analysis of the allele of GJB2 gene (rs 121011) and expression of conexin-26. The carriers of 35delG mutation of GJB2 gene with the decreased conexin-26 expression are delineated as the candidates at high risk of the sporadic sensorineural deafness with severe clinical course and unfavorable prognosis. |
