发明名称 |
MEASUREMENT OF BRAIN CDP-DIACYLGLYCEROL SYNTHASE 1 ENZYME AND USES THEREOF |
摘要 |
Provided herein are methods of diagnosing depressive disorders in a subject by comparing a CDP-diacylglycerol synthase 1 enzyme activity or expression level to enzyme activity or expression level of CDP-diacylglycerol synthase 1 in a control subject. Also herein are methods of predicting therapeutic efficacy of an antidepressant drug in a subject with depressive disorders by monitoring enzyme activity or expression level of CDP-diacylglycerol synthase 1 in the subject. Further provided herein are methods of identifying a compound effective to treat or alleviate the symptoms of depression by monitoring enzyme activity or expression level of CDP-diacylglycerol synthase 1 in a tissue. Further provided are kits for diagnosing depressive disorders. |
申请公布号 |
WO2014052415(A3) |
申请公布日期 |
2014.05.22 |
申请号 |
WO2013US61620 |
申请日期 |
2013.09.25 |
申请人 |
UNDIEH, ASHIWEL, S. |
发明人 |
UNDIEH, ASHIWEL, S. |
分类号 |
G01N33/50;A61K31/13;A61P25/24;C12Q1/25;C12Q1/68;G01N33/573 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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