发明名称 |
N-BICYCLIC ARYL,N'-PYRAZOLYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS |
摘要 |
Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome. |
申请公布号 |
WO2014078328(A1) |
申请公布日期 |
2014.05.22 |
申请号 |
WO2013US69747 |
申请日期 |
2013.11.12 |
申请人 |
ARRAY BIOPHARMA INC.;ALLEN, SHELLEY;BLAKE, JAMES F.;BRANDHUBER, BARBARA J.;JIANG, YUTONG;KOLAKOWSKI, GABRIELLE R.;XU, RUI;WINSKI, SHANNON L. |
发明人 |
ALLEN, SHELLEY;BLAKE, JAMES F.;BRANDHUBER, BARBARA J.;JIANG, YUTONG;KOLAKOWSKI, GABRIELLE R.;XU, RUI;WINSKI, SHANNON L. |
分类号 |
C07D401/14;A61K31/415;A61P25/28;A61P29/00;A61P35/00;C07D231/40;C07D231/44;C07D231/56;C07D401/04;C07D401/12 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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