发明名称 |
Method of inducing an immune response |
摘要 |
A method is provided for inducing or enhancing an immune response in a mammal to a target polypeptide expressed in a plurality of cells of the mammal, which method comprises administering to the mammal an inhibitory nucleic acid which targets a region of a ribonucleic acid (RNA) which encodes said polypeptide. Also provided is a pharmaceutical composition comprising an inhibitory nucleic acid which targets a region of an RNA which encodes a target polypeptide expressed in a plurality of cells of a mammal, such that translation of an aberrant form of the target polypeptide occurs in said cells, said truncated form of the target polypeptide comprising one or more T cell epitopes; together with a pharmaceutically acceptable carrier or diluent. |
申请公布号 |
AU2007344641(B2) |
申请公布日期 |
2014.05.22 |
申请号 |
AU20070344641 |
申请日期 |
2007.09.11 |
申请人 |
THE UNIVERSITY OF QUEENSLAND |
发明人 |
GU, WENYI;MCMILLAN, NIGEL;LEGGAT, GRAHAM |
分类号 |
A61K31/7088;A61P37/04;C12N15/11;C12N15/113 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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