发明名称 |
N-(ARYLALKYL)-N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS |
摘要 |
Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C, X, Ra, Rb, Rc, Rd and n are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome. |
申请公布号 |
WO2014078331(A1) |
申请公布日期 |
2014.05.22 |
申请号 |
WO2013US69750 |
申请日期 |
2013.11.12 |
申请人 |
ARRAY BIOPHARMA INC.;BLAKE, JAMES F.;BRANDHUBER, BARBARA J.;HAAS, JULIA;NEWHOUSE, BRAD;THOMAS, ALLEN A.;WINSKI, SHANNON L. |
发明人 |
BLAKE, JAMES F.;BRANDHUBER, BARBARA J.;HAAS, JULIA;NEWHOUSE, BRAD;THOMAS, ALLEN A.;WINSKI, SHANNON L. |
分类号 |
C07D403/12;A61K31/4155;A61P29/00;A61P35/00;C07D231/40;C07D231/52;C07D231/54;C07D401/04;C07D401/12;C07D401/14;C07D403/04;C07D413/12;C07D495/04 |
主分类号 |
C07D403/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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