Compositions and methods for treating collagen-mediated diseases
摘要
A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
申请公布号
AU2007211313(C1)
申请公布日期
2014.05.22
申请号
AU20070211313
申请日期
2007.01.30
申请人
AUXILIUM INTERNATIONAL HOLDINGS, INC.;BIOSPECIFICS TECHNOLOGIES CORP.
发明人
HITCHCOCK, ANTONY G.;DEL TITO JR., BENJAMIN J.;SABATINO, GREGORY L.;THARIA, HAZEL A.;BASSETT, PHILLIP J.