INSULINOTROPIC PEPTIDE DERIVATIVE IN WHICH ITS N-TERMINAL AMINO ACID IS MODIFIED

摘要

PROBLEM TO BE SOLVED: To provide an insulinotropic peptide derivative which is high blood stability and insulinotropic activity.SOLUTION: Insulinotropic peptide derivative is obtained by substituting 4-imidazoacetyl for an N-terminal histidine residue of native insulinotropic peptide. The native insulinotropic peptide is selected from exendin-4, exendin-3 and derivative thereof. The insulinotropic peptide derivative exhibits therapeutic effect, which are not observed in native and other insulinotropic peptide analog. The insulinotropic peptide derivative and the pharmaceutical composition comprising the same can be effectively provided for the treatment of diabetes.