INJECTION COMPOSITION CONTAINING POLYMER PARTICULATE OF WHICH INITIAL DRUG BURST IS REDUCED AND METHOD FOR PREPARING SAME

摘要

The present invention relates to a method for preparing an injection composition containing a polymer particulate of which the initial drug burst is reduced, and more specifically, to a method for preparing injectable polymer particulates of which the initial burst is reduced and which are filled with a drug, a polymer particulate prepared by the method, and the composition for injecting comprising same for delivering a drug, the method comprising the steps of: (a) preparing polymer particulates containing a polymer compound and the drug; (b) redispersing the polymer particulates of step (a) in a dispersion solvent; and (c) obtaining the redispersed polymer particulates from step (b) and processing same with an alcohol aqueous solution for 1 to 120 minutes. The polymer particulates according to the present invention has the reduced initial burst and injectibility, and thus can be effective in preparing the composition for injecting containing the polymer particulate as an active ingredient for delivering the drug.