发明名称 LIQUID FORMULATIONS FOR TNFR:FC FUSION PROTEINS
摘要 The invention provides stable liquid formulations for a recombinant biopharmaceutical protein comprising a soluble form of the human p75 TNF receptor fused to an Fe domain of a human immunoglobulin protein (TNFR:Fc ). Typically, biopharmaceutical proteins such as monoclonal antibodies (mAbs) and immunoglobulin fusion proteins (e.g., immunoadhesion proteins) are produced by recombinant DNA technology in mammalian cell expression systems. In order to guarantee the reproducible clinical performance of a biopharmaceutical product, manufacturers have to deliver a product of consistent and reproducible quality.
申请公布号 WO2014078627(A1) 申请公布日期 2014.05.22
申请号 WO2013US70248 申请日期 2013.11.15
申请人 MERCK SHARP & DOHME CORP.;KASHI, RAMESH, S.;PATEL, SHONA, P.;MITTAL, SARITA;BASARKAR, ASHWIN;SHI, SHUAI 发明人 KASHI, RAMESH, S.;PATEL, SHONA, P.;MITTAL, SARITA;BASARKAR, ASHWIN;SHI, SHUAI
分类号 A61K39/395 主分类号 A61K39/395
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