发明名称 |
PYRAZOLYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS |
摘要 |
Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome. |
申请公布号 |
WO2014078417(A1) |
申请公布日期 |
2014.05.22 |
申请号 |
WO2013US69897 |
申请日期 |
2013.11.13 |
申请人 |
ARRAY BIOPHARMA INC.;BRANDHUBER, BARBARA J.;JIANG, YUTONG;KOLAKOWSKI, GABRIELLE R.;WINSKI, SHANNON L. |
发明人 |
BRANDHUBER, BARBARA J.;JIANG, YUTONG;KOLAKOWSKI, GABRIELLE R.;WINSKI, SHANNON L. |
分类号 |
C07D403/12;A61K31/4155;A61K31/4412;A61P29/00;C07D401/14;C07D403/14 |
主分类号 |
C07D403/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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