NEW CELL-SPECIFICALLY ACTIVE NUCLEOTIDE MOLECULES AND APPLICATION KIT FOR THE APPLICATION THEREOF

摘要

The invention relates to cell-specifically active nucleotide molecules and an application kit for the application thereof. The aim was to modify long nucleic acid molecules in such a way that the biological function thereof is reliably inactivated by means of chemical modifications and can also be completely restored in a cell-specific manner. According to the invention, several peptides or polymers are bonded to nucleotide molecules in such a way that the spatial structure of the nucleotide molecules is changed so greatly that the biological function of the nucleotide molecules is no longer ensured or molecules that normally attach to the nucleic acids no longer gain access to the nucleic acid. Said molecules are used in particular in the cell-specific influencing of cells by introducing nucleic acids.