| 发明名称 |
INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM |
| 摘要 |
<p>Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., enteropathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.</p> |
| 申请公布号 |
EP2731600(A2) |
申请公布日期 |
2014.05.21 |
| 申请号 |
EP20120811724 |
申请日期 |
2012.07.13 |
| 申请人 |
MICROBIOTIX, INC. |
发明人 |
MOIR, DONALD, T.;AIELLO, DANIEL;PEET, NORTON, P.;WILLIAMS, JOHN, D.;TORHAN, MATTHEW |
| 分类号 |
A61K31/275;A61K31/165;A61K31/343;A61K31/353;A61K31/357;A61K31/402;A61K31/47;A61K45/06;C07D215/06;C07D217/12;C07D235/26;C07D311/58;C07D317/58;C07D319/08;C07D471/04 |
主分类号 |
A61K31/275 |
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