METHOD FOR NATIVE LIGATION OF POLYPEPTIDES

摘要

The invention mainly relates to a method for manufacturing a polypeptide of formula: X1—X″—X2  (III) X1 and X2 each representing a peptide fragment, and X″representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypeptide of formula: X1—N(CH2CH2SH)2  (I) and a polypeptide of formula: H—X″—X2.  (II) The invention also relates to the polypeptides of formula (I) themselves and the method for obtaining them, as well as resin supports suitable for obtaining them.