The invention relates to protein conjugates that contain a protein kinase containing a cysteine residue in the ATP binding site and an inhibitor that is covalently and irreversibly bonded to said cysteine residue, such that the activity of the protein kinase is irreversibly inhibited. The invention also relates to compounds that irreversibly inhibit protein kinases.
申请公布号
EP2478361(A4)
申请公布日期
2014.05.21
申请号
EP20100817748
申请日期
2010.09.15
申请人
CELGENE AVILOMICS RESEARCH, INC.
发明人
SINGH, JUSWINDER;PETTER, RUSSELL COLYN;NIU, DEQIANG;QIAO, LIXIN;KLUGE, ARTHUR;LOBB, ROY;GHOSH, SHOMIR;ZHU, ZHENDONG