METHODS FOR CELL REPROGRAMMING AND GENOME ENGINEERING
摘要
Methods for producing engineered induced pluripotent stem (iPS) cells are provided comprising introducing a first nucleic acid into somatic cells for integration into their genome and reprogramming the cells to produce engineered iPS cells having the nucleic acid integrated into their genome. For example, in certain aspects the cells are reprogrammed by introduction of a genetic element that expresses one or more reprogramming factor and culturing of the cells under conditions sufficient to produce reprogrammed cells.
申请公布号
EP2732029(A1)
申请公布日期
2014.05.21
申请号
EP20120736042
申请日期
2012.07.11
申请人
CELLULAR DYNAMICS INTERNATIONAL, INC.
发明人
BURKE, THOMAS;MILLER, MICHAEL;MCLACHLAN, MICHAEL;DICKERSON, SARAH;STROUSE, ANNE