发明名称 |
PHOTOSENSITIZING ANTIBODY-FLUOROPHORE CONJUGATES |
摘要 |
The present disclosure relates to compositions and methods of killing cells in vitro or in vivo. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein. In particular examples the antibody recognizes a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm-2, thereby killing the cell. Also provided are wearable devices that include an article of clothing, jewelry, or covering; and an NIR LED incorporated into the article, which can be used with the disclosed methods. |
申请公布号 |
EP2731626(A1) |
申请公布日期 |
2014.05.21 |
申请号 |
EP20120738664 |
申请日期 |
2012.06.27 |
申请人 |
THE UNITED STATES OF AMERICA, REPRESENTED BY THE S |
发明人 |
KOBAYASHI, HISATAKA;CHOYKE, PETER;BERNARDO, MARCELINO |
分类号 |
A61K41/00;A41D27/08;A61K49/00 |
主分类号 |
A61K41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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