发明名称 |
HUMAN BINDING MOLECULES CAPABLE OF NEUTRALIZING INFLUENZA A VIRUSES OF PHYLOGENETIC GROUP 1 AND PHYLOGENETIC GROUP 2 AND INFLUENZA B VIRUSES |
摘要 |
The present disclosure relates to binding molecules, such as human monoclonal antibodies, that bind to an epitope in the stem region of hemagglutinin of influenza A viruses of phylogenetic group 1 and group 2, as well as influenza B viruses, and have a broad neutralizing activity against such influenza viruses. The disclosure provides nucleic acid molecules encoding the binding molecules, their sequences and compositions comprising the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of influenza A viruses of phylogenetic groups 1 and 2, as well as influenza B viruses. |
申请公布号 |
EP2731967(A1) |
申请公布日期 |
2014.05.21 |
申请号 |
EP20120735516 |
申请日期 |
2012.07.12 |
申请人 |
CRUCELL HOLLAND B.V. |
发明人 |
KWAKS, THEODORUS HENDRIKUS JACOBUS;ZUIJDGEEST, DAVID A.T.M.;VOGELS, RONALD;FRIESEN, ROBERT HEINZ EDWARD |
分类号 |
C07K16/10;A61K39/00;A61K39/42;A61P31/16;G01N33/569 |
主分类号 |
C07K16/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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