FAST ASSIGNMENT OF ADEQUATE NEOADJUVANT CHEMOTHERAPY FOR BREAST CANCER PATIENTS BASED ON THE IDENTIFICATION OF CONSTITUTIONAL BRCA1 MUTATIONS

摘要

Disclosed is a method and composition for optimizing the efficiency of breast cancer neoadjuvant chemotherapy, depending on the particular constitutional genotype characteristics of the gene BRCA1 in each patient. Generally, the invention concerns a new method to improve neoadjuvant therapy depending on a particular constitutional genotype. Subject of invention allow to synthesize DNA and identification of germline BRCA1 genetic abnormalities which are correlated with a significantly decreased clinical response to neoadjuvant chemotherapy based on taxane-derived cytostatics in breast cancer patients.