CONDENSED HETEROCYCLIC NITROGEN COMPOUNDS AND USING THEM AS INHIBITORS OF AMYLOID BETA PRODUCTION

摘要

FIELD: medicine, pharmaceutics.SUBSTANCE: there are described new compounds of general formula [I]:or their pharmacologically acceptable salts, wherein Ris Calkyl; Ris Calkoxy; m and n mean 1; W means N; the ring A represents fragments of formula,orthat can be substituted; Xis a single bond, Calkylene group or -C(O)NR-, wherein Ris hydrogen, Calkyl or phenyl; and the ring B represents fragments of formula [5]-[11]:that can be substituted, and a pharmaceutical composition containing them.EFFECT: new compounds possess activity inhibiting the amyloid beta production, and are effective as a therapeutic agent for treating an A?-caused disease, such as Alzheimer disease or Down syndrome.10 cl, 48 tbl, 399 ex