发明名称 |
L-succinylaminoacylase and process for producing L-amino acid using it |
摘要 |
The present invention provides a L-succinylacylase consisting of: (a) a protein coded by a gene consisting of a nucleic acid sequence shown in SEQ ID No: 1; (b) a protein consisting of an amino acid sequence shown in SEQ ID No: 2; (c) a protein coded by a polynucleotide which hybridizes under a stringent condition with a nucleic acid sequence which is complementary to the nucleic acid sequence shown in SEQ ID No: 1 and having an L-succinylaminoacylase activity; or (d) a protein which consists of an amino acid sequence where one or several amino acid(s) is/are substituted, deleted, inserted and/or added in the protein consisting of the amino acid sequence shown in SEQ ID No: 2 and has an L-succinylaminoacylase activity. This enzyme is able to produce a sterically bulky unnatural amino acid such as L-tert-leucine etc. which is useful as an intermediate for pharmaceuticals. |
申请公布号 |
US8728771(B2) |
申请公布日期 |
2014.05.20 |
申请号 |
US200913139205 |
申请日期 |
2009.12.10 |
申请人 |
TODA ATSUSHI;IWAI SACHIO;NISHIYA YOSHIAKI;KUMAGAI SHINYA;TOYO BOSEKI KABUSHIKI KAISHA;SEKISUI MEDICAL CO., LTD. |
发明人 |
TODA ATSUSHI;IWAI SACHIO;NISHIYA YOSHIAKI;KUMAGAI SHINYA |
分类号 |
C12P13/04;C12N9/80;C12N15/00 |
主分类号 |
C12P13/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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