| 摘要 |
<p>The invention comprises compounds of the general formula <FORM:0999879/C2/1> (wherein R1 represents a C1-4 alkyl radical, one of the symbols X and Y represents a hydrogen atom and the other, together with R2, represents a C2-4 alkylene radical, with the proviso that the heterocyclic nucleus formed must be that of pyrrolidine or piperidine, and Z represents a -CH = CH- or -CH2-CH2-radical) and their acid addition salts and quaternary compounds, pharmaceutical preparations containing them together with a carrier and their preparation by removing the elements of water from a compound of the formula <FORM:0999879/C2/2> optionally followed by conversion to an acid addition salt or quaternary compound. The starting material may be prepared by reacting a compound of the formula <FORM:0999879/C2/3> with a compound of the formula <FORM:0999879/C2/4> (wherein Hal represents a chlorine, bromine or iodine atom), and hydrolysing the product. The pharmaceutical compositions have histamine-inhibiting, narcosis-potentiating, adrenolytic, anticholinergic, sedative, antipyretic, antiemetic, serotonin-inhibiting or hypothermic properties.</p> |
