发明名称 |
Recombinant butyrylcholinesterases and truncates thereof |
摘要 |
Isolated nucleic acids encoding polypeptides that exhibit butyrylcholinesterase (BChE) enzyme activity are disclosed, along with molecular criteria for preparing such nucleic acids, including codon optimization. Methods of preparing modified and/or truncated BChE molecules having selected properties, especially selective formation of monomers, are also described. Vectors and cells containing and/or expressing the nucleic acids are also disclosed. |
申请公布号 |
US8729245(B2) |
申请公布日期 |
2014.05.20 |
申请号 |
US201013517081 |
申请日期 |
2010.12.21 |
申请人 |
YIM KALVIN;DANSO STEVEN;HAUSKNECHT EDWARD;PHARMATHENE, INC. |
发明人 |
YIM KALVIN;DANSO STEVEN;HAUSKNECHT EDWARD |
分类号 |
C12Q1/46;C07H1/00;C07H21/00;C07H21/02;C07H21/04;C12N15/00;C12N15/52;C12N15/63;C12N15/66 |
主分类号 |
C12Q1/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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