发明名称 |
Process for the preparation of tapentadol and intermediates thereof |
摘要 |
The present invention refers to a new process for the synthesis of tapentadol comprising the quantitative resolution of the racemic mixture (V) to obtain the stereoisomer of (S)-3-(dimethylamino)-2-methyl-1-(3-nitrophenyl)-propan-1-one (VII) according to the Scheme 2 below using the (2R,3R)—O,O′-dibenzoyltartaric chiral acid wherein said resolution is quantitative. The present invention also refers to some intermediate compounds of the new synthesis process of tapentadol. |
申请公布号 |
US8729308(B2) |
申请公布日期 |
2014.05.20 |
申请号 |
US201013512989 |
申请日期 |
2010.11.30 |
申请人 |
MOTTA GIUSEPPE;VERGANI DOMENICO;BERTOLINI GIORGIO;EUTICALS S.P.A. |
发明人 |
MOTTA GIUSEPPE;VERGANI DOMENICO;BERTOLINI GIORGIO |
分类号 |
C07C211/00;C07C221/00;C07C223/00;C07C225/00 |
主分类号 |
C07C211/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|