发明名称 |
COMPOSTO, COMPOSIÇÃO FARMACÊUTICA, USO DE UM COMPOSTO, MÉTODO PARA TRATAR DOENÇA, E, PROCESSO PARA PREPARAR UM COMPOSTO |
摘要 |
According to the invention there are provided derivatives of a C21-deoxy ansamycin or salt thereof which contain a 1-hydroxyphenyl moiety bearing at position 3 an aminocarboxy substituent, in which position 5 and the aminocarboxy substituent at position 3 are connected by an aliphatic chain of varying length characterised in that the 1-hydroxy position of the phenyl ring is derivatised by an aminoalkyleneaminocarbonyl group, which alkylene group (which may optionally be substituted by alkyl groups) has a chain length of 2 or 3 carbon atoms, a phosphoric acid, or a phosphoric acid ester (such as an alkyl ester) group, or a salt thereof, and which derivatising group increases the water solubility and/or the bioavailability of the parent molecule. Such compounds are useful in therapy eg in the treatment of cancer and B-cell malignancies. |
申请公布号 |
BRPI0807376(A2) |
申请公布日期 |
2014.05.20 |
申请号 |
BR2008PI07376 |
申请日期 |
2008.03.03 |
申请人 |
BIOTICA TECHNOLOGY LIMITED |
发明人 |
STEVEN MOSS;CHRISTINE MARTIN;MING ZHANG |
分类号 |
C07D225/06;A61K31/395;A61P35/00 |
主分类号 |
C07D225/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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