| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to 5-membered heterocyclic compounds of general formula (I), their prodrugs or pharmaceutically acceptable salts, which possess xanthine oxidase inhibiting activity. In formula (I) T represents nitro, cyano or trifluoromethyl; J represents phenyl or heteroaryl ring, where heteroaryl represents 6-membered aromatic heterocyclic group, which has one heteroatom, selected from nitrogen, or 5-membered aromatic heterocyclic group, which has one heteroatom, selected from oxygen; Q represents carboxy, lower alkoxycarbonyl, carbomoyl or 5-tetrasolyl; Xand Xindependently represent CRor N, on condition that both of Xand Xdo not simultaneously represent N and, when two Rare present, these Rare not obligatorily similar or different from each other; Rrepresents hydrogen atom or lower alkyl; Y represents hydrogen atom, hydroxy, amino, halogen atom, perfluoro(lower alkyl), lower alkyl, lower alkoxy, optionally substituted with lower alkoxy; nitro, (lower alkyl)carbonylamino or (lower alkyl) sulfonylamino; Rrepresents perfluoro(lower alkyl), -A, -A-D-L-M or -A-D-E-G-L-M (values A, A, D, E, G, L, M are given in i.1 of the invention formula).EFFECT: invention relates to xanthine oxidase inhibitor and pharmaceutical composition, which contain formula(I) compound.27 cl, 94 tbl, 553 ex |
