发明名称 |
Down regulation of the gene expression by means of nucleic acid-loaded virus-like particles |
摘要 |
The present invention relates to compositions of virus-like particles for the introduction of RNA-interference (RNAi-) inducing molecules into eukaryotic cells and methods for the cell type-specific transduction of a plurality of eukaryotic cells with RNAi-inducing molecules. The present invention furthermore relates to methods for a diagnosis, prevention and/or treatment of diseases or disease states associated with an increased expression rate of at least one endogenous gene, and/or with the undesired expression of at least one endogenous gene and/or foreign nucleic acids, in particular viral nucleic acids. |
申请公布号 |
US8729038(B2) |
申请公布日期 |
2014.05.20 |
申请号 |
US20080678150 |
申请日期 |
2008.09.12 |
申请人 |
GRUBER JENS;JANSEN GABRIELE |
发明人 |
GRUBER JENS;LÜKE WOLFGANG |
分类号 |
C12N15/11;A01N63/00;C07H21/04;C12N15/113 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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