| 摘要 |
The present invention relates to a pharmaceutical combined formulation comprising metformin and an HMG-CoA reductase inhibitor, and a preparation method therefor, and more specifically, to a pharmaceutical combined formulation, and a preparation method therefor, the pharmaceutical combined formulation comprising: a first composition comprising a core layer comprising metformin or a pharmaceutically acceptable salt thereof and a water-insoluble polymer, and a hydrophobic base coating layer formed on the core; and a second composition comprising an HMG-CoA reductase inhibitor or a pharmaceutically acceptable salt thereof and a stabilizer. |
