发明名称 |
Protein-Polymer-Drug Conjugates |
摘要 |
A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by LP. Each occurrence of D is independently a therapeutic agent having a molecular weight≰5 kDa. LD and LP are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions. |
申请公布号 |
US2014134127(A1) |
申请公布日期 |
2014.05.15 |
申请号 |
US201414157154 |
申请日期 |
2014.01.16 |
申请人 |
MERSANA THERAPEUTICS, INC. |
发明人 |
YURKOVETSKIY ALEKSANDR;YIN MAO;LOWINGER TIMOTHY B.;THOMAS JOSHUA D.;HAMMOND CHARLES E.;STEVENSON CHERI A.;BODYAK NATALYA D.;CONLON PATRICK R.;GUMEROV DMITRY R. |
分类号 |
C08G6/00;A61K47/48 |
主分类号 |
C08G6/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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