发明名称 |
PROCESS FOR MAKING ABIRATERONE-3-ACETATE |
摘要 |
The present invention relates to an improved process for making abiraterone-3-acetate of formula (1) starting from dehydroepiandrosterone-3-acetate (DHEA) of formula (2). In particular, it relates to an improved process of converting the 17- triflate compound of formula (5) into abiraterone-3-acetate (1) in 2- methyl-THF as the solvent and producing a product of high purity via its acid addition salt abiraterone-3-acetate esylate (1A). |
申请公布号 |
WO2014071984(A1) |
申请公布日期 |
2014.05.15 |
申请号 |
WO2012EP72208 |
申请日期 |
2012.11.09 |
申请人 |
SYNTHON BV |
发明人 |
CASTULIK, JAKUB;GIELING, RENE;VYKLICKY, LIBOR |
分类号 |
C07J31/00;C07J43/00 |
主分类号 |
C07J31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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