发明名称 |
COMBINATION THERAPY WITH MDM2 AND EFGR INHIBITORS |
摘要 |
Provided is a method of treating a proliferative disease, condition, or disorder in a subject by administering a combination of an inhibitor of p53 and MDM2 binding and an EGFR inhibitor. Various embodiments of the disclosed methods provide a synergistic anti-proliferative or anti-apoptotic effect compared to administration of one agent alone. |
申请公布号 |
US2014134163(A1) |
申请公布日期 |
2014.05.15 |
申请号 |
US201414157086 |
申请日期 |
2014.01.16 |
申请人 |
ERRICO JOSEPH P. |
发明人 |
ERRICO JOSEPH P.;MUGRAGE BENJAMIN;TURCHI IGNATIUS;SILLS MATTHEW;ONG JANE;ALLOCCO JOHN;WINES PAM;BASTOS MARGARITA |
分类号 |
C07D401/12;A61K31/4709;A61K31/517;A61K39/395 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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