<p>The present invention relates to stable pharmaceutical compositions which contain polypeptides having at least two antigen binding domains and are particularly suitable for subcutaneous administration. The invention provides liquid compositions which minimize the formation of unwanted polypeptide aggregates (dimers and/or multimers). The present invention further provides a method of minimizing the aggregation of polypeptides having antigen binding domains in liquid compositions.</p>
申请公布号
CA2890166(A1)
申请公布日期
2014.05.15
申请号
CA20132890166
申请日期
2013.11.05
申请人
BAYER PHARMA AKTIENGESELLSCHAFT
发明人
OLBRICH, CARSTEN;BUNTE, THOMAS;WINTER, JONAS;PETERS, JORG;TRILL, THOMAS