METHOD FOR INACTIVATING TARGET TRANSCRIPTION FACTOR USING ARTIFICIAL SMALL INTERFERING PEPTIDE AND USE THEREOF

摘要

The present invention relates to a method for inactivating a target transcription factor using artificial small interfering peptide and to a use thereof. The present invention has prepared the artificial small interfering peptide (a-siPEP) which is a truncated form of a transcription factor that dimerizes and controls a transcription. The present invention also has identified that a-siPEP cooperates with the transcription factor to form a heterodimer so as to inhibit DNA binding of the transcription factor and nuclear transfer of the transcription factor, thus inactivating the relevant transcription factor in a protein level. A method for inhibiting the activation of a transcription factor using a-siPEP is a transcriptional control method with high accuracy and efficiency which may inhibit the activation of the transcription factor in a protein level in place of gene knock-out and which can be applied to both dicotyledonous plants and monocotyledonous plants.