| 摘要 |
Provided herein are methods for treating pain and for reducing the excitability of nociceptors, comprising administering a TGF-βantagonist. In some embodiments, a TGF-βantagonist is a monoclonal TGF-f3 neutralizing antibody or a fusion product comprising a monoclonal TGF-βneutralizing antibody, a soluble receptor, an antisense oligodeoxynucleotides (ODNs), a ribozymes, a small inhibitory RNA (siRNA), Smad 6, Smad7, or a small molecule that blocks TGF-βsignaling. |
