MEDICINE COMPRISING MODULATOR OF ACTIVITY OF CD300a-EXPRESSING CELL ASSOCIATED WITH ALLERGIC DISEASE, CD300a GENE KNOCK-OUT MOUSE, AND USE OF MODULATOR OF ACTIVITY OF CD300a-EXPRESSING CELL

摘要

Provided are: a medicine for an allergic disease (e.g., atopic dermatitis, asthma); and a tool useful for the analysis of a clinical condition of an allergic disease. A medicine, which contains a substance capable of inhibiting the binding between CD300a and phosphatidyl serine and comprises, as an active ingredient, an activity modulator that can inhibit the inhibitory signal transduction of a myeloid cell capable of expressing CD300a, can be used for treating or preventing an allergic disease. A CD300a gene knock-out mouse can be used for analyzing a clinical condition of an allergic disease or screening for a candidate substance that can act as an active ingredient for a therapeutic or prophylactic agent for the allergic disease, as a model mouse that rarely develops the allergic disease when a substance capable of inducing the allergic disease is administered to the mouse.