发明名称 TETOMILAST POLYMORPHS
摘要 <p>THE PRESENT INVENTION PROVIDES A TETOMILAST CRYSTAL THAT IS INDUSTRIALLY EASILY PRODUCED IN A LARGE VOLUME. (1) A TETOMILAST HYDRATE CRYSTAL HAVING A POWDER X-RAY DIFFRACTION SPECTRUM THAT IS SUBSTANTIALLY THE SAME AS THE POWDER X-RAY DIFFRACTION SPECTRUM SHOWN IN 2; (2) AN ANHYDROUS TETOMILAST TYPE A CRYSTAL HAVING A POWDER X-RAY DIFFRACTION SPECTRUM THAT IS SUBSTANTIALLY THE SAME AS THE POWDER X-RAY DIFFRACTION SPECTRUM SHOWN IN 4; (3) AN ANHYDROUS TETOMILAST TYPE C CRYSTAL HAVING A POWDER X-RAY DIFFRACTION SPECTRUM THAT IS SUBSTANTIALLY THE SAME AS THE POWDER X-RAY DIFFRACTION SPECTRUM SHOWN IN 8; (4) A TETOMILAST ACETONITRILE SOLVATE CRYSTAL HAVING A POWDER X-RAY DIFFRACTION SPECTRUM THAT IS SUBSTANTIALLY THE SAME AS THE POWDER X-RAY DIFFRACTION SPECTRUM SHOWN IN 10; AND (5) A MIXTURE CONSISTING OF THE ABOVE ANHYDROUS TETOMILAST TYPE A CRYSTAL AND AN ANHYDROUS TETOMILAST TYPE B CRYSTAL. THESE CRYSTALS ARE STABLE TOWARDS HEAT AND MOISTURE, AND ARE ALSO EXCELLENT IN TERMS OF THE DISINTEGRATION PROPERTY AND DISSOLUTION PROPERTY OF TABLETS. ACCORDINGLY, THESE CRYSTALS ARE PREFERABLY USED AS PHARMACEUTICAL COMPOSITIONS.</p>
申请公布号 MY151343(A) 申请公布日期 2014.05.15
申请号 MY2011PI04235 申请日期 2007.03.15
申请人 OTSUKA PHARMACEUTICAL CO., LTD. 发明人 AOKI, SATOSHI;NAKAYA, KENJI;SOTA, MASAHIRO;ISHIGAMI, MASASHI
分类号 C07D417/04 主分类号 C07D417/04
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